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However Incite the Pack happens randomly throughout the fight, whereas Primal Instincts kicks in right on pull, where the sims have you using Bloodlust, Prepot, Aspect of the Wild *and* Bestial Wrath you'll also be using Murder of Crows, have full focus and 2 charges of Barbed Shot hence your pet is going to have 3 Frenzy stacks for the entirely of the initial Primal Instincts buff. If you look at the Incite the Pack trait, it gives a similar amount of Mastery and has a 60% higher uptime compared to Primal Instincts (in my sims I get a 30% uptime for Incite the Pack, as opposed to a 19% uptime for Primal Instincts). It's not just about the large chunk of Mastery though, the timing of when the Mastery occurs matters a lot. Although the fact that the extra Mastery from the second and third traits still causes such a big DPS jump (relative to the first trait) implies that the Mastery is the largest contribution to the trait's strength in the first place. If you look at the stacked chart on Azortharion's Icy Vein BM Hunter guide, you'll notice that the first trait gives a slightly larger DPS increase (~23% larger) than the second and third trait. Yeah the Primal Instincts traits after the first only increase the amount of Mastery that you gain. Physicians can use this knowledge to better address the information needs of patients, potentially leading to better outcomes and more informed, empowered patients. Conclusion: Reddit provides valuable insight into atopic dermatitis patient gaps in knowledge regarding dupilumab therapy. Limitations: The questions of the “eczeMABs” subreddit subscribers may not reflect the questions of all atopic dermatitis patients. Usage instructions (13.4%) and general experience (8.0%) were common question categories as well. The greatest proportion of questions was related to side effects (36.3%), with patients most frequently inquiring about flares (25/95), ocular effects (17/95), and dry skin (10/95). 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